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Thus, Nox4 not only produces O2−, thereby directly contributing to oxidative stress in mitochondria, but also induces oxidative damage of mitochondrial proteins and causes leakage of O2− from mitochondria, which triggers a response known as ROS-induced ROS release [ 35].
Further, 2-DG not only blocked glycolysis, thereby lowering levels of ATP, but also impaired glycosylation, as addition of exogenous mannose was able to reverse ER stress and autophagy [ 71].
They are shunning them and flying out of regional airports instead, thereby not only sparing themselves a lot of aggravation but saving money to boot.
She thereby not only takes Mr. Bush off the hook for his disastrous decisions and policies, but also implies that her longstanding critiques of this president are merely predetermined by her genetic coding rather than arising from rational analysis.
In April, for instance, Estee Lauder, which had not yet created an online store for some of its brands, bought Gloss.com, thereby not only eliminating an online competitor, but giving Estee Lauder an online home for other brands within the company and significantly changing the competitive landscape in the beauty market.
Running to more than 2,000 pages and costing hundreds of millions of euros, the report concluded that Lowry proceeded to bypass consideration by his cabinet colleagues and thereby not only influenced but also delivered the result that Esat Digifone had won the evaluation process, ultimately leading to the licensing award.
The dilemma is that higher oil prices not only push up inflation (thereby calling for a rise in interest rates), but also dampen growth (requiring rates to be lower than otherwise).The best way to understand this is to use a standard economic diagram of aggregate demand and supply.
Bugs discovered in hardware during the software debugging phase require re-design and re-fabrication, thereby not only delaying the project but also increasing cost.
Polydopamine coating layer can act as an extraordinary glue to homogeneously adhere BPO4 nanoparticles on CNTs, thereby not only reducing the risk of short-circuiting, but also fabricating new proton-conducting pathways in the composite membranes.
