The upstream TFs would seem to play more critical roles in the gene regulatory network than do downstream TFs because they not only regulate genes but also regulate other regulators (TFs and miRNAs).
Based on this approach, our data suggest that transcription and splicing not only regulate gene expression, but also carry out combinational regulation of the balance between survival and apoptosis of HUVECs under mimicked hypoxia conditions.
Pericytes do not only regulate capillary integrity, but also the size of microvessels due to regulation of vessel constriction and relaxation.
The securities laws and rules not only regulate disclosure, but also set important timing requirements.
ncRNAs do not only regulate gene expression, but are also involved in chromatin architecture and structural conformation.
These bodies not only regulate the growing, production and processing of organic products, but also the labelling (including logos).
Thus FMS integrated-control systems not only regulate the times when machines operate but also the flow of parts.
Microenvironmental factors such as mechanical cues, soluble factors and matrix properties not only regulate MSC differentiation, but also modulate MSC signaling to the surrounding environment.
Furthermore, mechanical cues do not only regulate processes at a cellular level but also provide constant feedback about size and shape on a tissue scale.
Recent reports have shown that NRF-1 not only regulate mitochondrial oxidative genes but also controls MEF2A, the main transcription factor for glucose transporter, GLUT4.
However, metaphysical assumptions not only regulate the theoretical and empirical study of nature, but are increasingly supported by the growing empirical body of science.
