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MEK inhibition not only inhibited B7-H1 expression, but also sensitized blast cells expressing B7-H1 after stimulation with LPS to CTL-mediated lysis.
Dr. Fleming's contribution was his realization that something in the penicillium mold not only inhibited the growth of the bacteria but, more important, that it might also be harnessed to combat infectious diseases.
CG not only inhibited the development of cardiac hypertrophy but also improved ventricular function.
It not only inhibited the formation of biofilms but also disrupted the established Staphylococcus aureus and Escherichia coli biofilms.
We found that AT-MSCs not only inhibited the Ig-production but also suppressed this B-cell function to a much greater extent compared to BM-MSC.
Glycoconjugates 13 and 14 not only inhibited both viral propagation with IC50 values in low micromolar range, but efficiently suppressed the production of viral proteins in a dose-dependent manner.
In our study, we unexpectedly found that Baicalin not only inhibited the differentiation of TH17 cells but also promoted TGF-β-mediated differentiation of Treg cells in vitro.
Interestingly, SB431542 not only inhibited the reduction of AP-activity, but even seemed to increase AP-activity dose-dependently (Figure 2C).
Unexpectedly, NaTPI activity in vitro assays not only inhibited the trypsin sensitive fraction of gut proteinase activity but also halved the NaTPI-insensitive fraction in third-instar larvae.
Notably, our study revealed that GS not only inhibited the constitutive PI3K/Akt pathway, but its pre-treatment abrogated both ST and nicotine induced activation of PI3K/Akt pathway.
Taken together, these results suggest that IFN-β not only inhibited the IL-17 production by direct or indirect routes, but also prevented Th17 polarization through modulating IL-6 secretion.
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