Ixabepilone is not only active against paclitaxel-sensitive xenografts, but also demonstrates significant activity with paclitaxel-resistant human tumor models including breast carcinoma, ovarian cancer, and colorectal cancer xenografts [ 22].
Importantly, NAMI-A differs from most of the so-called anti-metastatic agents in that it is not only active in preventing metastasis formation but shows also good activity in inhibiting those already formed and in advanced stage of growth, this effect being very likely responsible for the increased survival time of the treated animals (Sava et al, 1999b).
This facilities not only active solubility and dissolution of F−-bearing minerals, but also activate anion exchange between F− and OH− (Robinson and Edington 1946; Hem 1991), which favours the increase of F− content in the groundwater.
Recent studies describe GFP variants that are not only active if translocated in their folded form via the twin-arginine translocation (Tat) pathway, but actively fold in the periplasm following general secretory pathway (Sec) and signal recognition particle (SRP) mediated secretion.
Therefore, the controllers should be able to deal with not only active but also passive robots.
By the time he was 2, he was not only active but also well coordinated.
THE New England athenaeums I visited on a recent trip maintain not only active memberships, but also some peculiar terminology.
So employers reach not only active jobseekers but also a much larger pool of passive candidates through referrals.
Nobody investigates the dealings of Atos, who are not only active in Britain but will soon also be taking care of "benefit reform" in eastern European countries.
Landscape sensitivity for landscape management must, therefore, address not only active, largely nonlinear, environmental systems, but also the mosaics and palimpsests that are the inheritance from past environments.
Among them, the piperazinone-based inhibitors were found to be not only active against factor Xa but also selective over thrombin.
