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Recently researches confirmed that Sitagliptin and exendin-4 can not only activate the phosphorylation of AMPK but also inhibit the activation of MAPK including p38 and ERK [ 15- 18].
However, given the results of the Kahn et al. study cited above; overactivation of the hippocampus could not only activate the TPJ, but could potentiate this region over time.
Hence, MBL binding to endothelial cells might not only activate the complement system but also enable contact of MASP-1 with endothelial cells in order to trigger proinflammatory reactions by cleaving PAR4.
We also reported that the shrimp NF-κB family proteins LvRelish and LvDorsal can not only activate a shrimp AMP luciferase reporter in Drosophila S2 cells, but that they can also bind to putative NF-κB-binding sites in the AMP and WSSV069 (ie1) promoter regions.
Studies of healthy populations suggest that experimental psychological and physical stressors not only activate the ANS [ 23] and the HPA axis [ 24], but also influence the immune system by activating innate immunity, as reflected by increased numbers of natural killer (NK) cells and the production of pro-inflammatory IL-6 [ 15, 16].
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In our study, the activated HER2 not only activated the PI3K/Akt and mitogen-activated protein kinase signaling pathways but also enhanced FASN activity by direct interaction and phosphorylation, leading to an increase in cell invasion.
Thus, we argue that glutamine not only activated the AT activity of the C-terminal AT domain but also altered the conformation of this domain in such a way that the interactions between domains of ATase were altered.
Thus, a drug like pilocarpine not only activates the constrictor muscle but actively inhibits the dilator.
We reported recently that expression of Ano6 in HEK293 cells and activation by ionomycin not only activates a Cl−, but also a nonselective current.
For example, caspase 3 is not only activated during myogenesis, but also its activity is required for the initiation of myogenic differentiation [6], [7].
Overexpressing WT Rab2A not only activated Erk1/2 but also surprisingly colocalized with activated Erk1/2 at the perinuclear region at 5 min and 1 hr after EGF stimulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com