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Glu181 is suggested to be the counterion in the Meta III state of the mutant and appears to be capable of stabilizing a protonated Schiff base in Meta III, but not of constraining the receptor in an inactive conformation.
The model captures the variation of the strength with grain size, film thickness, and with the presence or not of constraining surface layers, in agreement with experimental results on Al and Cu films.
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The study also reveals that the canons do not seem capable of constraining the Justices to vote against ideology and that noncanon tools of analysis, including precedent and practical-consequences-based reasoning, lead to higher rates of dueling than do most traditional canons or tools of statutory interpretation.
And so this would not be a case of "constraining the conceptual structure".
Students who do not engage, either because of constraining circumstances such as being time poor or as a result of a lack of interest in excelling, are unlikely to significantly benefit from formative assessment tasks (Smith, 2007).
"But in practice, the promoters of the missile defense want a large one, and they don't like the idea of constraining it".
Mr. Leibler said his mission was "not to constrain the art of architecture with a business overlay".
Last month, Opec decided to stick with its policy of not constraining output.
A large metabolic core was indeed found in the union-networks of the subset of the Chlamydiae and Proteobacteria phyla, but this is an effect of the close phylogenetic relationship of these species, and not of a constraining chemistry.
He, like the rest of us, had not fully appreciated that moral norms were not constraining the behaviour of those competing across complex and interlocked global entities that covered both shadow and formal banking systems.
Such cue-priming of action is pathological in the sense of not being constrained by the desires of the individual.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com