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Mice that received scAAV8.FIXR338L (n=7), but not mice receiving WTFIX vector (n=5), expressed 57 120% factor IX and six of seven mice demonstrated joint protection with histopathological features that did not differ from those of injured hemostatically normal wild-type mice.
Mice treated with the peptide vaccine, but not mice who had not received the peptide vaccine, showed carrier-specific T cell responses (Fig. 6c).
Mice that received anti-MPO IgG but not mice that received control IgG developed a pauci-immune focal necrotizing and crescentic glomerulonephritis.
Mice expressing A53T α-synuclein (line M83), but not mice expressing wild type α-synuclein, develop adult-onset progressive motor deficits.
If not mice, weevils.
Humans are not mice, of course.
In both cases, of course, the researchers' long-term interest is not mice but people.
"Because, after all it's humans we treat in the clinic, not mice".
If you want to understand the human immune system, try studying humans - not mice.
You cloners ought to be making frogs and toads, not mice.
AhR mRNA expression was increased (P < 0.05) by VCD dosing in small pre-antral follicles isolated from ovaries of rats but not mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com