Sentence examples for not in checkpoint from inspiring English sources

We have known for some time that Fhit protein is, directly or indirectly, proapoptotic (Ji et al, 1999; Sard et al, 1999; Dumon et al, 2001; Ishii et al, 2001), so perhaps the difference in Fhit-positive and -negative cells at the G2/M boundary is not in checkpoint or cycling defects but in sending or responding to an apoptotic signal.

Overexpression of the SP chk1 gene in Sz. pombe leads to cell death with un-attenuated checkpoint arrest, and this lethal phenotype was only compromised in SP rad24 deletion mutants, but not in other checkpoint-defective rad mutants (Ford et al. 1994).

Surprisingly, the mismatch repair system does not play a role in checkpoint activation, at doses and duration of NEU used in the experiments.

Fig. 5C shows that in contrast to cdc13-1 rad9Δ strains cdc13-1 and cdc13-1 mrc1Δ strarrestrrest at medial nuclear division with similar kinetics at 36 °C, supporting the idea that Mrc1 does not play a role in checkpoint activation after cdc13-1 telomere uncapping.

Because plating efficiencies in the mutants were not reduced from wild type levels, changes in checkpoint recovery were not indicated.

There was not a checkpoint in sight.

We conclude that CaMKII is involved in the radiation responsive signalling pathway mediating S phase checkpoint but not in the p53-dependent pathway controlling G1/S checkpoint, and that a wortmannin-sensitive kinase functions upstream in both pathways.

It was at a West Bank checkpoint, not in Jerusalem.

This difference in checkpoint responses was not due to a reduced rate of DNA replication in control cells, which would lead to a reduced incorporation of cytarabine (Figure 2B).

Giving that the checkpoint is activated largely through protein phosphorylation and kinase cascades, the emerging role of protein phosphatases in checkpoint recovery is not surprising [ 27].

In the last few years evidence has emerged that the role of NER in checkpoint activation is not limited to the generation of the ssDNA signal but, in addition, NER proteins seem to be involved in directly recruiting checkpoint factors to the proximity of DNA lesions.