Binding of ATP to the ATP pocket does not fully trigger the RNase-activating conformational change in Ire1, arguing against the model that ATP pocket occupancy is sufficient to lock Ire1 into the active conformation and to activate RNase.
Such inter-racial mixtures accounted for the existence of liminal individuals, whose physical traits seem to lie between the discrete boundaries of one of the four races; peoples who do not fit neatly into one or another race are explained away as groups whose seeds have not been fully triggered by the appropriate environmental stimuli (Bernasconi and Lott 2000, 11).
The LPS model used in this study does not fully recapitulate the events triggered by bacterial pathogens and their toxins in the foetal brain, and reproduces only part of the inflammation-mediated effects.
But, how sister separation is triggered is not fully understood.
What determines which of the two opposing responses is triggered is not fully understood.
Thus, the question about canalization vs. expansion of plasticity in response to selection will remain not fully resolved until specific trigger mechanisms measurable in ancestral and evolved genotypes can be identified.
On the other hand, in single phase type I materials crack initiation in the VHCF-regime start from the surface of the specimen, triggered by repeated, not fully reversible plastic deformation in the grains adjacent to the surface.
Although how yeast cells trigger mitophagy is not fully understood, oxidative stress is likely to be a signal to induce Atg32 expression.
Inhibition of AQP3 expression significantly reduced but did not fully prevent the increase in cell volume triggered by the nucleoside-derived drugs in MCF7 and HT29 cells.
The pathogenesis of the vasculopathy is not fully understood, but a viral trigger, immune reactions to viral or environmental factors, reperfusion injury, or antiendothelial antibodies may all be involved [ 1].
