The gene encodes a 486 amino acid chromatin-associated protein that consists of three domains; a methyl-binding domain, a transcription repression domain, and a third domain on the C-terminal region that has not been fully functionally characterized [13].
Thus, far, enzymes from Groups 1, 2, 4, and 6 have not been fully functionally characterized, although the three-dimensional structures for some proteins have been determined.
There are more than 140 TRs common among the members of the Burkholderia genus that have not been fully functionally annotated.
Far away from the soma, thin fibers, probably axonal collaterals, arise from these POMC dendrites, suggesting that dendritic and axonal functions are not fully separate spatially or functionally [ 193].
The relationship between EILP and αLP is not fully characterized even though EILP seems to functionally overlap with αLP in their ability to differentiate into ILCs but not T/B cells.
Although their role in humans is not fully understood, a cellular population phenotypically and functionally similar to mouse FAPs has been isolated from human muscle.
However, the mechanisms of MMP gene regulation are still not fully delineated, and it is likely that many more functionally important elements in their promoter regions are yet to be identified [ 143– 143].
Hence, we chose a γ value of 0.75 (midpoint of 0.5 and 1) to identify highly connected (but not fully connected) subgraphs as most probable modules that are functionally associated with phenotype-related query proteins.
Although the mechanisms linking DNA methylation of SOCS3, SREBF1, SBNO2, CPT1A, PRR5L, and LY6G6E to BMI, and of TXNIP to T2D are not fully established yet, some of these genes have been already functionally linked to metabolic phenotypes.
