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"The cost is not fully delineated," he said.
However, the mechanisms that mediate transformation in MPNs are not fully delineated, and clinically utilized JAK inhibitors have limited ability to reduce disease burden or reverse myelofibrosis.
Although the mechanisms underlying the cytotoxicity of iron in different organs are not fully delineated, many reports have pointed to the participation of iron-mediated peroxidation in numerous pathological states, including atherosclerosis [46], [47], cancer [48], [49], ischemia-reperfusion injury [50], IBD [51], and conditions of iron overload [52].
The underlying mechanisms are however not fully delineated so far.
However, the exact mechanism of ACHBLF is not fully delineated.
Endocrine tumours are highly vascularised and the molecular mechanisms of their angiogenesis are not fully delineated.
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The potential benefits of hepatectomy for patients with HCC have not been fully delineated.
To date, the mechanism underlying these contrasting stress effects has not been fully delineated.
The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes.
However, the molecular pathways underlying alterations in energy metabolism and increased dependency on glycolysis have not been fully delineated.
The requirement for RAIDD in various paradigms of cell death has not been fully delineated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com