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Importantly, as the mouse prion protein is not exclusively expressed in neurons, the expression driven by the mouse prion protein promoter occurs not only in CNS neurons, but also at substantial levels in glial cells especially in astrocytes [ 117, 181].
We could show that Fkbp5 is often, but not exclusively, expressed in regions also known for GR expression, for example the hippocampus.
Cells in growth medium expressed OP and alkaline phosphatase (data not shown) gene expression, suggesting these genes are not exclusively expressed by osteoblasts.
Although the VEGFRs are not exclusively expressed on vascular cells, there is prominent expression and important function of VEGFR1 on hematopoietic and endothelial cells, of VEGFR2 on vascular endothelial cells and of VEGFR3 on vascular and lymphatic endothelial cells (LECs).
Means of expression for both genes in samples S1 and S2 showed an induced expression, suggesting that the genes were not exclusively expressed in the wounded area (Fig. 6).
To further characterize the CD34pos selected population, the mRNA expression of genes known to be preferentially but not exclusively expressed in stem cells, such as the self-renewal factor gene BMI1 and the pluripotent state-specific transcription factor genes OCT4 and NANOG, were analyzed.
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We found that the Gad65-GFP virus did not exclusively express GFP within inhibitory neurons, as assessed by fluorescent in situ hybridization (FISH), but when this virus was used to transduce CeA neurons, the majority of the neurons that expressed GFP were in fact inhibitory neurons and this was likely due to the fact that this nucleus contains a very high percentage of inhibitory neurons.
To circumvent potential developmental effects of htauAP on DA neurons, we used a conditional expression system by incorporating temperature-sensitive GAL80ts [ 27] in our model to predominantly, if not exclusively, expressing htauAP in adult brains.
The targeted cell type might not be exclusively expressed in the inflamed joint or the probe might bind to irrelevant targets, resulting in non-specific signals and low target-to-background ratios.
For example, we would not detect genes exclusively expressed during prenatal life as no samples from these stages were represented in the current atlas.
Although loss-of-function mutations in nAChR subunits that are also expressed in muscle (i.e. unc-29, unc-38, unc-63 ) result in locomotory defects, gene knockouts of acr-2 (Y. Jin, personal communication) and acr-12 (data not shown), which are exclusively expressed in neurons, do not produce obvious effects on motility or behavior.
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