Early last week, when the 10-member selection committee for the N.C.A.A. men's tournament was sequestered in an Indianapolis hotel, the task of picking and seeding the field of 65 teams did not appear to be exceedingly difficult.
These network patents are sometimes granted in the US and the EU but not many; it is exceedingly difficult to isolate the patentable attributes of networks of genes that are modeled as interactive and related to a wider biological context in its complexity (see Calvert 2007 2008).
Predicting identities of "new" species, not previously curated, is exceedingly difficult.
ODQ greatly enhanced the sensitivity of both artery types to U46619 (not shown), making it exceedingly difficult to match pre-constriction amplitudes to those obtained without ODQ, despite a reduction in U46619 concentration.
Although we know quite well how to manage individual fields of agricultural crops or stands of trees to make them less prone to disturbance and disease, devising efficient risk-mitigation and response strategies at the landscape or even country scale is exceedingly difficult (not least because most of our understanding of risk factors comes from small- to medium-scale observations and experiments).
It's not as if it's exceedingly difficult to rip a CD these days.
The main conclusion that can be drawn from this is that these hurdles will be exceedingly difficult, if not impossible, to overcome and will therefore require alternative approaches if fermentative H2 is to become an important method of fuel production in the future.
According to Vanguard spokeswoman Linda Wolohan, the company is "required to manage all funds in the interest of all shareholders, so it would be exceedingly difficult if not impossible" to take political and social issues into account unless it started affecting the bottom line, a major goal of the House legislation.
The latest research makes clear that such warming would make it exceedingly difficult if not impossible to feed 9 billion people post-2050 -- and would likely force us to ultimately abandon major coastal cities around the world.
I've spent enough time in the U.S. government to know that coordination across the hallway, let alone with distinct agencies or departments, is exceedingly difficult, but not impossible.
