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Five patients receiving intermittent capecitabine required treatment interruption and/or modification, but not discontinuation, to control the following adverse events: neutropenia (one patient), hand foot syndrome (two patients), pyrexia (one patient) and hypotension plus pyrexia (one patient).
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Most ISR-AEs were mild and did not require discontinuation.
Other features included not requiring discontinuation of current analgesic therapies and blinding investigators to study design elements that could contribute to non treatment-related responon treatment-related
Our case, in conjunction with the summary of previously published cases, suggests that ocular complications can be managed with corticosteroid therapy if other systemic irAEs do not require discontinuation of therapy.
The stones are treatable and do not justify discontinuation of the diet.
When 52% of the U.K. population votes to leave, yet 70% of those voters didn't really care to understand the repercussions of their vote, tragedy if not business discontinuation is knocking at the door very quickly.
Moderate: the adverse event interfered with the individual's daily activities; it may have required additional therapy, but did not require discontinuation of the study agent.
Non-significant adverse events were events that did not warrant discontinuation from the clinical trial.
Most adverse events are grade 1 or 2, and do not require discontinuation of therapy.
Histopathological response was correlated with clinical response (P<0.001), but not with discontinuation of chemotherapy.
Subject responds to air stimulus but does not request discontinuation of stimulus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com