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Even as we grow older, it's not difficult to appreciate the masterfulness of the good doctor's words.
It is not difficult to appreciate the anger aroused by the idea of Evans pulling on the red and white stripes of Sheffield United and trotting out again in front of cheering fans.
It is not difficult to appreciate the adaptive significance of a process that results in animals approaching places where they have found food in the past, or in learning that a particular novel object is in fact an example of food, and directing food-related activity toward these stimuli in the future.
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However, given that most patients die from non-breast cancer causes, affecting the OS, it would not be difficult to appreciate the potential value of PET, especially in patients with ER-rich tumours, as well as a number of significant co-morbidities further shortening their life expectancy (the median time of progression on PET regardless of H-score in this study was 49 months).
And if you are not undocumented, it is difficult to appreciate the angst of doing so without a licence.
I acknowledge that the enormous importance of this may be difficult to appreciate if you're not a semi-feudal politician, but work with me.
If you haven't been to the Middle East in summer, it's difficult to appreciate how hot it can be.
These findings do not appear to be due to nuclear staining being more difficult to appreciate in the presence of strong cytoplasmic staining, as there was a positive correlation between nuclear and cytoplasmic FIH (Spearman r=0.318, P<0.001).
It was difficult to appreciate on T1-weighted imaging and did not enhance with contrast, indicating it might have been thick fluid.
Despite the accessibility of this technique, it is very difficult to appreciate the detail in wiggling pictures and does not actually give true depth perception.
Along with altered chromosome number and aberrations, the complexity of cancer cells is difficult to appreciate by cytological analysis alone, as uniparental isodisomy may not be detected.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com