Hence, a significant proportion of fetal chromosomal abnormalities are not detectable by current noninvasive methods.
Addressing minimal residual disease that is not detectable by current imaging methods would provide TIL with a potentially more favorable (Th1) environment, and less antigenic burden.
The observed loss of progesterone receptor could be through a range of mechanisms, including the generation of alternatively spliced progesterone receptor variants that are not detectable by current screening methods.
On the other hand, large genomic rearrangements are not detectable by current PCR-based methods, perhaps explaining the discrepancy between linkage analysis and genetic testing.
One further possibility is that alternative splicing of PR pre-mRNA might generate cancer specific PR variants that are not detectable by current pathological screening methods, thus leading to potential misdiagnosis of a tumour as PR-.
This article briefly describes this approach and gives specific examples that depict the ability of molecular imaging to detect occult lesions not detectable by current scintigraphic approaches.
Most are not detectable by current testing processes which is why prisoners prefer them.
One study suggests that "as a rule" mixtures below the NOAEL should present no health concern (interactive effects were reported at the LOAELs) (Cassee et al. 1998), whereas another suggests that even low-level exposure to chemical mixtures may cause subtle biologic effects, some of which may not be detectable by current methods (Yang 1994b).
However, even if donor management and tracing were flawless, the fact that prionuria may exist well before the onset of clinically overt prion disease, without being detectable by current methods, remains a cause for concern.
During this period it is likely that replication takes place but without accumulation of PrPd to levels detectable by current methods.
Novel methods taking multiple loci at a time into account may offer possibilities of detecting interactions not detectable by classical methods.
