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The 4T1 model does not need immunocompromised mouse hosts and shows rapid metastasis to all inner organs and bone, which is not completely achievable with MDA-MB-231 cells.
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Even the best change vision and strategy may not be completely achievable because of a failure to convince everyone about its importance or viability.
"The concept of a level playing field is aspirational, but I'm not sure it's ever completely achievable," said Wally Renfro, a vice president and special adviser to the president of the N.C.A.A. "So do I see there's going to be a change in that regard?
Nonetheless, the virtually complete retrieval of a genome from a single Prochlorococcus cell confirms that generating draft-quality, if not completely closed, genomes is an achievable goal for single-cell genomics.
Although the long-term effects of radiation exposure are not completely predictable, the principle of keeping radiation exposure "as low as reasonably achievable" should be used.
The slightly reduced number of recombined cells in PLP-NCre x PLP-CCre mice compared to the maximal recombination achievable in PLP-Cre mice (Fig. S3, S4) can be attributed to not completely overlapping expression patterns of the PLP-NCre and PLP-CCre transgenes in the respective mouse lines.
But it's actually, Gates tells me, completely achievable.
"Mick said we might need 38 points and it is completely achievable.
Not completely.
"And perhaps it is, but we are confident it is completely achievable.
Well, not completely.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com