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This is particularly the case in An. funestus, for which pyrethroid resistance is caused by metabolic resistance and not by target site resistance, such as mutations in the voltage gated sodium channel gene.
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This was achieved not by targeting the active site but rather by geometrically impacting loop motifs analogously to ribosome antibiotics.
The results indicate that activity of O. africana extracts is not by targeting the cell membrane.
These data verify that BAFs detoxify Abeta42 not by targeting toxic oligomers, as requested by the reviewers.
It is possible that the activity against a desired target is caused not by the target itself but rather by an activity at another downsteam or upstream location.
When Ms. Swift released "Red" she was promoted not only by Target, Walgreens and Keds sneakers, but also on pizza boxes from Papa John's.
The ability to provide this type of EMF requires no foreknowledge of a target's presence or absence and is not impacted by target prevalence rates.
The cell-killing activity is completely inactivated by 30 min at 60 degrees C, but it is not absorbed by target cells during 1 h of incubation.
A similar phenomenon occurs in case of circular polarization, where helicity is reversed by the medium but not by the target.
For example, CXCL1 mRNA expression in HCT116 cells was up-regulated by CQ treatment but not by siRNA targeting Atg5 (Fig. 5a).
The job of beating the Germans was prolonged, not shortened, by targeting German civilians.
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