We don't become relevant by going along with every change of public opinion.
And if you've lost any of those constraints and any of the world then it doesn't become relevant.
This is like the first time you ever saw that Michael Gove clapping tweet: it didn't become relevant until he went full bumbling evil post-Brexit, and then we rolled out the clap reminder, and his house of cards collapsed beneath him.
Circumstances can change in the meantime, and there is the possibility of members of the collaboration growing towards each other, without forcing the other to take a position on something that might not even become relevant in the future.
Similarly, an argument that is ineffective because it is not understood can become relevant once the audience is better informed.
To this end, our data from the present study indicate that the pro-apoptotic gene, noxa, although significantly induced, may possibly not become a relevant therapeutic target for the treatment of ischemic stroke.
As a result, tools and services like wikis, social networking sites, online forums, blogs, and social tagging tools have become relevant not just in everyday life but also in the context of learning and education.
At the highest, most rostral end of the hierarchy, frontopolar cortex encodes information which is currently not required, but which may become relevant in the near future (not shown in Fig. 1).
There's a particular part of his answer, however, that was not only unambiguous, but would also become relevant later in the day.
