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It does not need to have quotation marks around it, it should not be underlined, and it should not be in italics.
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"Somebody like Di Maria doesn't come along very often and the amount of hope that he can give a club can't be underlined either.
On the other hand, central corneal thickness is a KC clinical feature, which does not have to be underlined by all genes involved in KC pathogenesis.
However, it has to be underlined that not all parts of a molecule contribute equally to its affinity for plant cuticles.
On the first page, children of 8 years and older must identify and underline pairs of target letters that are physically identical (e.g., TT but not Tt), whereas on the second, pairs of letters that have the same name (e.g., Aa not Ba) are targets to be underlined.
Finally, it should be underlined that not all the functional deterioration observed in these subjects is necessarily attributable to the fracture and no data are presented for a control group; however, the objective of this study was not to measure the effect of a hip fracture on functional loss, but rather to characterize patients with poor functional prognosis.
The "not" in "do not disclose" is underlined three times.Yes.Yes
Although a high frequency of lung involvement in patients with severe kidney disease was observed in other series [ 7], the clinical significance of this association had not yet been underlined.
Accordingly, the importance of mismatch repair proteins Msh2 and Msh3, but not Msh6, was underlined in inducing repeat instability in model cell lines containing expanded GAAs [Edward Grabczyck, personal communication as presented at the 4th International Friedreich's Ataxia Conference (http://www.curefa.org/conference.html)].
Differences in expression levels between the respective groups were statistically not significant which were underlined by the Western blot data of the benign and malignant mammary cell lines.
As if Louis-Dreyfus' words extolling her father weren't enough, they were underlined by the actress' trembling as she struggled to contain her emotions, her hands shaking so visibly that it appeared to hinder her reading from her notes. .
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com