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It is likely that the double-blind design of that study meant that pain transition could not be optimised.
European guidelines are based mostly on western European data raising concerns locally that recommended treatments might not be optimised for the situation in Hungary.
Secondly, the network should not be optimised for any particular application.
This stems from two epoch-making design decisions made by its creators in the early 1970s: that there would be no central ownership or control; and that the network would not be optimised for any particular application: all it would do is take in data-packets from an application at one end, and do its best to deliver those packets to their destination.
In total, 973 primer pairs were designed (including redesigned primer pairs to replace those which could not be optimised).
Current techniques employing simple descriptors of the histogram of parameter values, although more sensitive than simple ROI analysis, may not be optimised to detect the changes caused by a new agent in a phase I trial.
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High critical thresholds have not been optimised since they correspond to the station capacities.
This may be because the FLAB implementation we used had not been optimised for the reconstruction protocols or types of objects used in this study.
Commercial buildings are found significantly more energy intensive than their residential counterpart, mainly due to the fact that BEE policy has been poorly implemented and architectural design has not been optimised in commercial sector.
It is clear that all three forms of PPARs have mechanistically different modes of lipid lowering and that drugs currently available have not been optimised on the basis of PPAR biology.
First, you may not need to do anything: your site may already be optimised.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com