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New annotation can be viewed by the modeller, even if the other species are not annotated yet.
For example, about 50% of the predicted genes in P. falciparum are not annotated yet, suggesting that our compiled metabolic network is not complete.
The tool can also help to disclose new associations among genes cooperating in hidden biological processes not annotated yet, which can be revealed by the topology of the functional network.
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In S. cerevisiae the gene encoding for this enzyme has not been annotated yet.
This high number of novel sequences might be due to the fact that the genomes of the other NHP species are not sufficiently annotated yet.
Indeed, the unexpected finding of a high abundance peak of RNAs with 25 nt or more in length lead us to the finding of rRNA and tRNA genes that have not been annotated yet in the sorghum genome.
A possible explanation for this discrepancy is that transcripts without a proposed function could be either species-specific or the corresponding transcripts have not been annotated yet in related species.
Since, the recently sequenced cucumber genome has not been functionally annotated yet, we searched for homologous proteins for these cucumber transcripts in the NCBI protein-database (www.ncbi.nlm.nih.gov) in order to infer the biological functions of their predicted targets.
Most of the functional genes have not been completely annotated yet.
Since switchgrass genes have not been well annotated yet, rice orthologs of the differently regulated transcripts were identified.
Reference species such as Arabidopsis and P. trichocarpa can provide tremendous insights into A. mangium small RNA functions where the genome of this species is not sequenced and annotated yet.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com