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In IPF, autophagy pathways are not activated but rather impaired [59].
B cells from cKS and HSP subjects were not activated, but rather expressed lower levels of costimulatory molecules than B cells from HCs, and this was equally evident on CD27− and CD27+ cells.
Currents carried by mSlo3 co-expressed with hLRRC52 were also not activated, but suppressed by Ca2+.
Not only were stress response pathways not activated, but the response to bortezomib was blunted in cells with reduced PSMD2 levels.
Thus at a time when the carbachol receptor is not activated, but the store has released Ca2+ in response to agonist, Ca2+ entry and depolarization are stimulated, resulting in contraction.
However, during early chronic infection, Notch signaling is not activated but in subsequent stages of cirrhosis and HCC, there is an enhanced expression of Notch family genes in the liver and associated increased hepatic TGF-β signaling and emergence of CD4+ FoxP3-expressing T cells probably contributing to fibrogenesis.
Similar(52)
Contrary to previous reports in other cell types, ca-PKCι did not activate, but rather decreased, baseline NF-κB activity in a luminiscence reporter assay.
Thus, for at least one TLR ligand, poly I C, T cells may be activated directly; for flagellin, despite clear expression of TLR5, T cells are not activated directly, but require the presence of accessory cells.
These experiments established that the phospho-mimetic S177E mutation had not activated IKKβ, but permitted IKKβ to auto-activate by phosphorylating Ser.
This pathway is not activated by stress, but functions in the C. elegans germline during oocyte production [33], [34], similarly to apoptosis during oocyte production in humans.
In some fMRI studies investigating cortical processing of optic flow, V1 was activated [4], in others it was not activated [1] but its role in motion processing has never been discussed in that context.
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CEO of Professional Science Editing for Scientists @ prosciediting.com