Plasma NO and NOS levels were significantly higher in the POTS group than in the control group (NO 74 ± 19 μmol/L in POTS group vs 62 ± 6 μmol/L in control group, p <0.01; NOS 21 ± 3 U/mL in POTS group vs 15 ± 1 U/mL in control group, p <0.01).
However, expression of endothelial NOS, levels of nitrate/nitrite – indicative of NO production – remained unchanged between cerebral microvessels of wild-type and eGCH-Tg mice.
Nevertheless, in vitro GC have significant effects on the NO system, including reducing endothelial and inducible NOS levels, reducing l-arginine and co-factor availability as well as inhibition of transmembrane l-arginine transport [ 63, 64].
Vardenafil treatment significantly reduced apoptosis protease activating factor 1, endothelial NOS and inducible NOS levels in the vardenafil group compared with the T/D group.
By contrast, Nos levels are quite variable in pgc PGCs.
In parasite-damaged midgut cells, the increase in NOS levels was concurrent with other morphological changes associated with apoptosis [ 41].
