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The bioavailability of NO is dependent on the presence of reactive oxygen species (ROS) that oxidize NO and uncouple NOS, preventing NOS from producing NO [ 5].
NO is generated by NO synthase (NOS) from L-arginine in vivo [ 2].
NO is produced by NOS from its primary substrate, L-arginine.
Since NO is synthesized by NOS from L-arginine, increases in L-arginine concentration should increase the activity of NOS, and thereby overcome the excitatory effect of L-NAME.
Endogenous NO is produced by nitric oxide synthase (NOS) from the substrate L-arginine.
NO is a free radical gas formed by the enzyme NOS from the substrate L-arginine.
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