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An antimetabolite is similar in structure to a metabolite, or enzymatic substrate, which is normally recognized and acted upon by an enzyme to form a substance required by the cell.
Fellows are normally recognized for a substantial body of scientific work, which makes election before the age of 40 years unlikely.
Reprograming is often accomplished by designing novel protein or RNA parts that respond to specific small molecules not normally recognized by the natural chemosensory pathways.
Here, Changeux approvingly quotes Joëlle Proust: "A philosophical theory is naturalistic when it recognizes as legitimate only those objective undertakings and explanatory principles normally recognized and adopted in the natural sciences" (p. 135).
"The job description shows that the new role will not be a chief executive in any sense normally recognized in either the private or public sectors," said Peter Riddell, director of the Institute for Government.
Although it has always been considered that it is difficult for a PV jet of low flow rate to penetrate the TBL, it is found in this study that the TBL is penetrable even at invading velocities lower than the normally recognized value of 0.3 m/s.
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"This provides a snapshot into a process we geologists don't normally recognize — the role of seismicity," he said.
"Essentially, we're converting T cells that would normally recognize other types of cells to be tumor specific," Levine says.
By dissecting the roles of different genes and proteins in the lymphoma cells, Staudt and colleagues have uncovered what appears to go wrong in this cancer: Genetic mutations cause B-cell receptors, proteins on the B cell's surface that normally recognize infections, to send signals into the cell that block a self-destruction process that normally helps rid the body of abnormal cells.
Mexican nationals rarely win asylum cases, partly because the U.S. government doesn't normally recognize organized crime as a valid reason to grant asylum.
The modularity of the ZF proteins, both in structure and function, serves greater advantage in comparison with other types of DNA-binding domains (DBDs) that normally recognize DNA as dimers and use non-modular recognition domains [7], [8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com