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This unexpected inactivity in the reporter gene assay suggests that bisphenol AF binding disrupts the ERβ-LBD activation conformation, in which the α-helix 12 (H12) of the receptor is normally positioned to recruit the coactivator protein conformation (Brzozowski et al. 1997; Ruff et al. 2000).
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Notably, a more severe defect was observed in the posterior peak of Hb expression (Figure 6B), that is normally positioned at 80 to 88% of EL [34].
OAD is a physical vapor deposition technique in which the substrate is normally positioned at a large angle with respect to deposition vapor direction.
In contrast, the mitotic signaling kinase Aurora B was normally positioned at the cleavage furrow in dividing HFF-shp53+GpIbα cells (Figure 4F), showing that the mislocalization was specific to a subset of cytokinesis proteins.
In contrast, early genetic tests, based on classical tetrad analysis, estimated that unlinked loci are normally positioned at ~139 kb (Cherry et al. 2012), a distance ~4-fold greater than our estimate of 35 kb.
Moreover, the duplications are normally positioned near to orthologs also found in the genomes of some distantly related bacteria.
While Box A is normally positioned close to the transcription start site, the location of Box B is variable, partly because some tRNAs have short introns within the coding region.
In the case of tRNA genes, the promoter consists of two conserved elements: Boxes A and B. While Box A is normally positioned close to the transcription start site, the location of Box B is variable, partly because some tRNAs have short introns within the coding region [ 8, 11].
Deep layer neurons appeared to be normally positioned.
Those who received prenatal surgery were half as likely to have a shunt, and eight times as likely to have a normally positioned brainstem.
The early apoptotic cells tend to exhibit phosphatidylserine on outer cell membrane, which is normally positioned across the inner membrane [ 35] and it has a strong binding affinity to annexin V [ 36].
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