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Lowering the temperature of a euthermic subject to a temperature below that normally maintained by homeostasis reduces the metabolic rate, and hence the demand for oxygen and substrates by the tissues.
Being a boat rocker by nature, Inspector Montalbano upsets Vigàta's political stability -- normally maintained by collusion of the police, the press, the Mafia, the church and the politicians -- by insisting that a local power broker did not die of natural causes.
A wide variety of oxidizing molecules such as ROS and/or depleting agents can alter glutathione redox state, which is normally maintained by the activity of GSH-depleting (GPx, GST) and GSH-replenishing (GR) enzymes (Halliwell 1996).
Major temples were normally maintained by the kings and a salary was paid from the royal treasury to those who worked in the temple, unlike in India and rest of Sri Lanka, where religious establishments were autonomous entities with large endowments of land and related revenue.
Nevertheless, we note that the cold-sensitivity of the hcf-1 deletion phenotype probably reflects the temperature sensitivity of a process (e.g., mitosis) that is normally maintained by the Ce HCF-1 protein, rather than cold sensitive function of Ce HCF-1 itself.
The sequence files are normally maintained by the former.
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Safehouses are usually maintained by nonprofit organizations.
In wild-type animals, DAF-16 is normally maintained in the cytoplasm by inhibitory phosphorylation from the IIS-activated AKT kinases that are activated downstream of AGE-1 and PDK-1 (Fig. 1A).
Because of the potential cellular toxicity that results from the accumulation of carbonylated proteins, their intracellular levels are normally maintained at very low levels by proteolytic removal.
Extracellular ATP is normally maintained at low nanomolar levels by a ubiquitous ecto-ATPDase (CD39), although in an inflammatory milieu, ATP may be released from dead or injured cells, as well as by cell swelling or from autonomic nerves [ 15].
Having a short half-life, p53 is normally maintained at a low level in unstressed mammalian cells by continuous ubiquitination and subsequent 26S proteasome-mediated degradation.
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