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Even in highly proliferating cells such as stem cells and stimulated lymphocytes, which activate hTERT expression, the low levels of assembled telomerase RNP complexes are normally insufficient to maintain constant telomere length throughout life and only slow down the rate of shortening.
The second mechanism is the modification of gene expression in the cells participating in the immune response, permitting lymphocytes to respond to signals normally insufficient to initiate a response or allowing the antigen-presenting cells to abnormally stimulate a response.
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This counting-based approach is needed because the limited number of experiments normally available for non-model organisms are usually insufficient to predict regulatory links from the expression data.
The yield of the crop is normally low because of insufficient moisture in the soil.
The initial damage caused by an injury is normally the result of insufficient metabolic supply.
use one irrigation before the start of the rainy season if total rainfall is normally expected to be insufficient for a complete leaching.
Maternal insulin secretion normally increases in response; if insufficient to overcome the insulin resistance, hyperglycaemia occurs.
Normally, constipation occurs because there is insufficient amount of water in the stool which makes it hard and difficult to pass.
Moreover, real moderate altitude training camps normally last 3 weeks, which is an insufficient time to achieve the target, although the hypertrophic training must be carefully adapted to avoid the undesired results previously mentioned.
This normally occurs when a single IP's resources are insufficient for maintaining the high availability of an application through redundancy.
Subsequently, a prolonged life span of FLSs was recognized (reviewed in [ 68, 69]), although even a combination of enhanced proliferation of the normally slow growing FLSs plus defective apoptosis seems an insufficient explanation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com