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Billups has not played at his normally high level since he sat out six games with a thigh bruise.
They argued that the normally low sensitivity of IP3R1 to IP3 was required to assure that calcium release is confined to the activated dendritic spine while the normally high level of IP3R assures robust calcium release despite the low sensitivity.
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The normally high levels of inorganic salts found in urine were not added, in order to eliminate the effect of salt suppression in the various sample introduction interfaces.
They find a requirement for lipoproteins in mediating LTP recruitment to DRNs and that LTP function at DRNs is necessary for normally high levels of Insulin signaling.
Accordingly, inhibition of ROS using N-acetyl cysteine (NAC) following radiation treatment drastically decreases senescence in tumor cells with normally high levels of radiation-induced SA-β-gal.
Hernjak et al. demonstrated that the normally high levels of IP3R1 ensure robust calcium signals in an individual spine, and that the normally low sensitivity of IP3R1 to IP3 confines the calcium transients to the stimulated spine, without spillover to adjacent spines [ 35].
The latter result suggests the effects on PER rhythm produced by loss of these two signaling systems are confined to those pacemaker that normally have high level expression of PDFR and CRY.
We also showed that the ITT concentration needed to activate spermatogenesis is considerably lower than the normally occurring high level.
To address this, we knocked down MRJ-L in macrophages with normally high expression levels (from donor 6) (Fig. 4a, western blot, left).
For example, it has been shown that in the presence of 5azaC, the inhibitory effect of glucose on the expression of hGH-V (human placental growth hormone) is reduced, as 5azaC hypomethylates hGH-V (normally, high glucose levels lower the endogenous hGH-V mRNA) [ 45].
To confirm the inhibitory role of MS4a4B in T cell propagation, we used synthesized siRNAs to silence expression of MS4a4B in T32 cells, a T helper cell line derived from normal primary T cells, which normally expresses high levels of MS4a4B protein [1].
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