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hIAPP normally complements insulin by suppressing postprandial glucagon secretion, helping to regulate the rate of gastric emptying, and inducing satiety.
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However, this is expected because error-clamp trials probe only the anticipatory (feedforward) forces and do not elicit any reactive (feedback) forces that would normally complement predictive compensation [ 11].
In yeast we show that PD-linked VPS35 mutations are functional and can normally complement VPS35 null phenotypes suggesting that they do not result in a loss-of-function.
Efficacy studies, which normally complement practice guideline development, are those performed in highly selected groups of patients to investigate if a particular intervention works under controlled conditions set by the study investigators.
We employed yeast as a model to demonstrate that mutations equivalent to D620N in a highly conserved yeast ortholog of VPS35 (i.e. D686N) can normally complement growth phenotypes in Δ vps35 yeast thereby indicating that the D → N substitution at this highly conserved residue does not compromise VPS35 function.
Similarly, testes from a M/+ animal harboring wild-type clones (labeled M+), which normally predominate in a M/+ heterozygous background, contained a normal complement of GSCs (Supplementary Fig S6B).
As a result of this, a normal complement of oligodendrocytes and myelin can be produced, and the mice develop, survive, and behave normally [ 86].
Inappropriate activation of complement is normally prevented by complement inhibitors.
Cdc5T238D can function normally, because it complemented cdc5-1 cells and rescued growth defect of kog1-105 cells (Figure 5B).
Those genes produce complement regulatory proteins that normally mediate the activities of complement, a system of proteins responsible for the breakdown of immune complexes and defense against infection.
The complement system normally operates at pH 7.4 that is the normal pH from blood and extracellular fluids.
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