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Normalization of MI values reduces the effect of positional entropy and phylogenetic bias [54], and several normalized variants of MI have been proposed.
Martin et al. were the first to use normalized variants of mutual information to correct for bias coming from variable alphabet size among columns [2].
The final version of the corpus contains 105 abstracts available with 109 normalized variants and 155 unnormalized ones.
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Normalized variant counts per exon were compared with expected counts using a 1 degree of freedom χ test.
All normalized variant expression values were compared with WT GKRP as the reference standard using an unpaired (two-tailed) t-test.
To address the issue of bias towards superficial sources known in MNE, we also included in our evaluation two noise-normalized variants of MNE: dSPM and sLORETA.
In the present study, we will compare the performance of cMEM with MNE method and two noise-normalized variants of MNE dynamic statistical parametric mapping (dSPM) (Dale et al. 2000) and standardized low-resolution electromagnetic tomography (sLORETA) (Pascual-Marqui 2002).
This vector is weighted and normalized by the tf, df and normalization variants of the weighting schemes (WS).
The histograms in Fig. 4 show the level of each variant normalized to the wild type, but for the purpose of statistical analysis, samples were not normalized to the wild type reference.
To obtain an estimate of nucleotide diversity in Syncytin-1 gene transcripts in brain, the normalized numbers of variant sites was calculated by dividing the number of observed nucleotide changes by the length (base pairs) of the sequence and the correcting for the sample size (n) as described [39].
The normalized number of variant sites, heterozygosity, and MAFs were significantly different by functional SNP category in TERT and CLPTM1L (P values <0.01; Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com