The normalized transit-times of representative cells from the screened mixture are shown in Figure 3C.
The normalized transit-time distributions for all cells measured for each marker screened are also shown in Figure 2C.
Each dashed box corresponds to a single cell and contains the normalized transit-times corresponding to the markers screened (τCD13, norm = orange, τCD14, norm = red, τCD15, norm = blue, τCD33, norm = pink).
The range of normalized transit-times in each distribution is due to cells having different expression levels of a particular surface marker: as we have shown previously, cells with higher expression levels will have a greater number of interactions with the functionalized antibodies and in turn longer transit-times as compared to those cells with lower expression levels.
Here, σisotype is the standard deviation of the normalized transit-time values we measured when we screened a sample of cells with a node-pore consisting of only multiple isotype-control segments (see SI). Figure 2C shows the phenotypic profiles of 10 individual NB4 and AP-1060 cells.
Again, defining positive expression for a particular surface marker as τnorm > 1 + 2σisotype (SI), we determined Patient 1, 2, and 3′s normalized blast-cell transit-time distribution for each surface marker, as shown in Figure 4B.
Mass transit operated normally.
It is found that all responses transit to the half space results when the normalized thickness (film thickness to tip curvature radius t/R0) is larger than about 0.08 for PZT4, and degenerate to the dielectric half space solutions as expected for rigid and dielectric substrate case, when the normalized thickness approaches zero verifying the calculations.
The sums of probabilities transit from each action to another action are normalized to be 100.
Fig. 6 A plot for the normalized bond distance differences as a function of coordinates (CRH HRH, TS, HRH) obtained from the linear transit calculation of quinoline bound with the reductive half reaction active site of Qor.
