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In addition, several plasma cytokines/growth factors/chemokines triggered by the tumor growth were normalized, providing a rationale for combination therapy with an HDACi and a JAK2/FLT3 inhibitor for the treatment of AML patients, particularly those with FLT3 or JAK2 mutations.
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Normalized features provide better separation of attention classes.
These normalized affinities provide us with a meaningful parameter for assessing the fluxes of energy for different catabolic reactions into a system.
As raw data are only available for some of the microarray datasets, we used the "normalized" data provided by submitters.
Briefly, optical data were demodulated to identify source-detector pair signals; signal intensities were normalized to provide a relative change of intensity.
These normalized ranks provide the basis for our downstream analysis.
All data, both raw and normalized, is provided [see Additional file 3].
The RNA was quantified (A260 absorbance measurements) and normalized to provide the same amounts of each mRNA sample to the cell free translation mix.
This is calculated based on the MSA obtained The above calculation is further normalized as provided in [ 89], (9) s j = 100 × 1 − 0.334 × S j Crystal structures where available for the shortlisted proteins were obtained from PDB [ 90].
The sway path length calculated over this normalized posturogram provides a scale free measure of the amount of 'twisting and turning', in which larger SP n values indicate more twisting and turning [ 22].
To confirm these findings, we also evaluated all PCs in each normalized dataset provided by Haibe-Kains et al. [ 6] and observed that among 483 PCs significantly explained by either one of the predictors, the PAM50 explained 2.27 times more independent variation in expression than the SCMGENE assay.
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