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The following fit measures were used: Comparative Fit Index (CFI), Goodness of Fit index (GFI), Adjusted Goodness of Fit index (AGFI), Normalized Fit Index (NFI) and Non-normalized Fit Index (also known as Tucker-Lewis Index) (NNFI).

GF indices were: Root mean square error of approximation (0.031), GF index (0.97), and normalized fit index (0.92).

Lastly, the following goodness of fit indicators were calculated: Root mean square error of approximation (RMSEA), goodness of fit index (GFI), adjusted goodness of fit index (AGFI), comparative fit index (CGI), and normalized fit index (NFI).

Starting with the resulting model fits, the residual error over time of the fitted trajectories throughout the cohort (visit 1, Figure 4a ) is comparable with Subject 117 (11% absolute normalized fit error, cohort: 12%).

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Then, the sum of squares of the normalized fit-error on all metabolites was minimized.

Regarding Rasch analysis, the normalized item fit statistics are presented in Table 6.

Whole-brain fMRI volumes were realigned to the first volume, coregistered to each participant's anatomical data, and normalized to fit a standard brain template (structural T1 images).

The ICA spatial map was converted to a z-statistic image via a normalized mixture model fit and then thresholded at z = 3. Selected sections in Montreal Neurological Institute (MNI) space at coordinates z = −16, z = −12, z = −7, z = −2, z = 8, z = 14, z = 20, z = 70.

This raw emission ratio was corrected for photobleaching and normalized by fitting a single exponential function to the emission ratio trace and dividing the latter by the fitted function; thus all ratio changes were expressed in terms of changes in fluorescence, ΔR/R.

The dI/dV curves at each temperature are normalized by fits using Eq. 8, as shown by the solid curves.

Data curves are averaged from 3 individual measurements, normalized and fitted according to the model of Boltzmann.

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