Exact(5)
ROC curve analysis of discrimination between cases with active CD and normalized CD revealed an AUC of 0.90 for anti-TG2 and 0.78 for TNFRSF9 mRNA.
Differences in expression in normalized CD cases alone could not be investigated, because all but two cases had one DQB1*02 allele.
One of the two CD cases with remaining enteropathy on a GFD that were misclassified based on anti-TG2 (see Clinical antibody tests) showed a level of the TNFRSF9 mRNA marker for normalized CD that was below the 80% CR of the group with normalized CD and within the 80% CR for the group with active CD (Additional file 2).
Previously established CD markers (anti-TG2, anti-DGP, and anti-GL) were differentially expressed in active CD cases in comparison to cases with normalized CD (p < 0.005) as well as cases without a CD diagnosis (p < 0.00005).
Additionally, TNFSF13B mRNA levels were significantly elevated in cases with confirmed CD and normalized histology (Table 1; Normalized CD), in comparison to cases without a CD diagnosis (p = 0.001, Figure 1, Additional file 2).
Similar(55)
Figure 5 shows the normalized C-V characteristics of the InN MIS structures at 1 MHz.
Figure 1 Formation enthalpies of Mg Ga /Mg Al and normalized C Mg cprofile of AlGaN films.
Figure 2 pH Sensitivity and linearity characteristics and normalized C-V curves.
The pH sensitivity was calculated from the slope of output voltage, which is obtained at the 0.6 Cmax of the normalized C-V curves.
In contrast, in a cohort of 339 critically ill patients (11% with a history of diabetes) with stress-hyperglycemia and markedly elevated c-peptide levels, intensive insulin therapy targeting normoglycemia reduced endogenous insulin secretion and normalized c-peptide levels [8].
(b) Normalized C-V curves for the ALD-HfO2 and 3.5-nm-thick ALD-HfO2-EIS structure measured at pH 2 to pH 12. Considering the application on biomedical sensors, the stacked structure of 15-nm-thick HfO2/50-nm-thick SiO2/Si EIS was used.
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