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Further, AJN is shown to normalize DAT, D2R and TH levels in the striatum of morphine dependent animals.
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Additionally, post-treatment with medium or high dose of AJN normalized DAT and D2R expression in morphine dependent rats, which confirms that AJN can effectively act on the dopamine system.
Additionally, groups post-treated with AJN-L, AJN-M, and AJN-H displayed DAT expression at 86.9 ± 3.2%, 98.8 ± 3.3% and 100.3 ± 2.8% of the level observed in the control group, respectively, indicating that post-treatment with AJN-M and AJN-H normalized DAT expression in morphine dependent animals.
(d) Relative DAT levels normalized to total β-actin are indicated.
This response however fails to normalize terminal function and potentially contributes to the motor deficit observed (i.e. excessive DAT may contribute to reduced synaptic DA and result in motor dysfunction).
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