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Indeed, in an experimental glioma model, intratumoral vascular normalization restored blood brain barrier properties by suppressing edema formation [ 118] and a clinical study showed increased blood perfusion in GBM after anti-angiogenic therapy [ 138].
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In vivo and in vitro gene silencing of p66Shc after glucose normalization restores endothelium-dependent vasorelaxation and, decreasing ROS production, inhibits apoptosis [ 133].
Normalization was restored following editing.
First a process of "normalization" to restore the city's population balance to what it was before Mr. Hussein's decrees, then a census, then the referendum.
In those cases, the administration of Mg rapidly restored normal levels of calcium through the normalization of PTH synthesis and action.
Interestingly, these alterations could not be restored to normal despite normalization of glucose levels, suggesting a metabolic "memory" of human endothelial cells in response to transient but rapidly changing glycemic milieu [ 89].
This does not mean, however, that the commonly used normalization procedures can restore the true correlations.
PACs function can be restored by glucose normalization, as shown in islet-transplated type 1 diabetic patients [ 37].
In vivo, fat mass was restored upon the normalization of ROS, which is associated with suppressed adipocyte dedifferentiation and downregulated apoptotic and autophagic markers.
During the reconstruction phase, normalized data is first restored and a scaling procedure which is exactly the inverse to the normalization is applied to finally reconstitute the data in its original form.
In contrast to the current hypothesis that vascular normalization improves chemotherapy delivery, we hypothesize that restored BBB function will actually decrease drug delivery [ 22].
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