Sentence examples for normalization platform from inspiring English sources

Further, datasets and analysis are required to determine which factors (e.g. normalization, platform and laboratory) have significant effects on the accuracy of our procedure.

While yielding a good metabolomic coverage (Additional File 1, Figure S1), multi-platform data may, even after normalization, contain platform-specific biases that have adverse effects on data integration methods.

PAM50 and SCMGENE subtype call differences obtained in the UNC337 dataset (GSE18229) with and without a platform normalization step.

We describe the use of eight spikes for an accurate normalization of the platform and in our experience this conditions allows an accurate normalization in every experiment.

We found that the CV was less than 10% when the number of replicates was equal or greater that 200 and we concluded that a minimum of 200 replicates is needed for an accurate normalization of the platform.

On the basis of a Monte Carlo resampling procedure we determined that theoretical minimum number of five spikes each replicated 48 times is needed for the normalization of our platform.

The genes that make up a gene expression signature are by their nature dependent on the patient and tumour characteristics, array platform, normalization method and statistical thresholds for gene selection or the classification algorithm employed.

The Prosigna algorithm therefore requires no additional cohort or platform normalization, providing a stable and unchanging subtyping algorithm that can be applied to a single patient sample or to a biased patient population (such as all hormone receptor positive) with both accurate and stable results [ 29, 30].

Another recently published comparison of cross-platform normalization methods also found XPN to have the highest inter-platform concordance [ 37].

After the initial normalization using a platform-specific tool, the data can be further normalized to specific genes or samples.

Normalization of cross-platform data has been previously described [21], [22], [23] with very good correlations and consistency between the CodeLink and Affymetrix platforms [24], [25].