Sentence examples for normalization methodologies from inspiring English sources
That paper specifically states, "The normalization methodologies do not explicitly reflect two important factors driving losses: demand surge and loss mitigation.
The normalization methodologies evaluated in FREEC are: GC content, mappability and control genome.
We evaluate in detail the effect of normalization methodologies in two CNV algorithms FREEC and CNV-seq using whole genome sequencing data from 8 individuals spanning four populations.
We use multiple configurations corresponding to different read-count normalization methodologies in FREEC, and statistically characterize the concordance of the CNV calls between FREEC configurations and the analogous output from CNV-seq.
The first analytical approach (Method I) involved the use of normalization methodology and subsequent estimation of the errors accounted for by dye and genotype effects upon the signal as determined via a linear model.
The GC content normalization methodology generates the highest number of altered copy number regions.
Because BANNER + Lucene, BANNER + cosine similarity and DNorm (BANNER + pLTR) use the same processing pipeline, the performance difference between these methods is solely due to the normalization methodology.
Choice of read-count normalization methodology has a substantial effect on CNV calls and the use of genomic mappability or an appropriately chosen control genome can optimize the output of CNV analysis.
Total RNA levels were multiplied by copy number to correct for the division of reads amongst copies that occurs during mapping, or alternate normalization was applied in Figure 4 figure supplement 2 (see below for the reasoning underlying this copy number normalization methodology).
Using this approach not only can mRNA levels be validated, but also differences in microarray methodology, normalization and data processing methods.
Standardization of '-omics' methodology, normalization of the terminologies of herbs and herbal formulas and expanding research on herbal synergy with system biology will improve the quantity and quality of the databases, thus making integration more easily be achieved.
