Although previous research [ 53] has suggested relatively high robustness of microarray data analysis to different types of normalisation techniques, more evidence clearly indicates that prediction outcomes can be significantly affected by the selection of normalisation methods [ 29- 32].
Nevertheless, the clear conclusion of the present work that Ntx levels in the normal range are associated with a much-reduced incidence of skeletal events, together with corresponding previous findings for pain and quality of life, provide strong evidence that normalisation of bone resorption should be a major aim of therapy.
Following data normalisation, executed in two steps, first using within-slide loess normalisation followed by quantile between slide normalisation, we employed linear models [49] to rank the differentially expressed genes in order of evidence (i.e., P value) of differentially expressed genes.
Complete remission was defined as an absence of clinical or radiological evidence of disease and normalisation of urinary catecholamines.
Fifty Shades of Grey patently revisits "Bluebeard", and although it is extremely hard to see what the reasons are for the book's extraordinary success, it certainly provides evidence of a widespread naturalisation – normalisation – of sadomasochistic fantasy.
A complete response was classified as normalisation of tumour markers with no clinical or radiological evidence of residual disease at the completion of treatment.
In addition, evidence for significantly improved outcomes with normalisation of NLR after the first cycle is promising for possible manipulation of the systemic inflammatory response through targeted anti-inflammatory mediators such as IL-6 blocking antibodies.
This was interpreted as evidence that the intervention resulted in a normalisation of the cortisol response.
Based on previous evidence, 9 the primary outcome measures were normalisation of ALT and AST.
At this stage, there is insufficient evidence to support delaying RTS based on normalisation of isokinetic function.
