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A normal trafficking but absent enzymatic function characterizes mutations of phenotype III.
The G3 region appears to be essential for normal trafficking of the aggrecan within the chondrocyte and for its secretion into the extracellular matrix (ECM) (Zheng et al. [1998]).
This study was designed to investigate the trafficking of Andes virus (ANDV) and Sin Nombre virus (SNV) glycoproteins and to determine if ANDV or SNV glycoproteins G1 and G2 could be substituted for each other while still retaining normal trafficking.
Correction or restoration to the normal trafficking process by TfR may be a strategy that merits exploration and further investigation.
The normal cardiac phenotype of this L212P carrier is in good agreement with the normal trafficking and the mildly affected electrophysiological properties of L212P channels (Table 3).
Highly responsive cells also express more coatomer-complex proteins, important for normal trafficking of secretory proteins from ER to cis-Golgi [18].
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