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Although the behavior of Scn8a heterozygous mutants is outwardly normal, systematic testing recently revealed behavioral abnormalities in mice heterozygous for a null allele of Scn8a on the C57BL/6J strain background (13).
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In Kuhn's own view, as a historian and philosopher standing high above the fray, it is deliberate, systematic normal research that will most readily sow the seeds of revolution and hence of rapid scientific progress.
However, Makarenkov et al. (2007) have reported that it failed to recover correct hits in a scenario with 'noisy standard normal data with systematic error stemming from row × column interactions which are constant across plates'.
Histograms of WRES and CWRES appeared approximately normal, with no consistent systematic residual trends.
The mixed model emphasises patterns of change and individual differences and assumes not a normal distribution but rather systematic change.
Because values remained within normal limits and no systematic changes were found, the differences are most likely related to multiple testing.
The key process outcome of a case conference, which is not present in normal care, is the systematic consideration of all aspects of end of life care.
The purpose of the course entrance examination was to promote revision, as the students had already been taught normal structures in a systematic way during the first year of their studies.
To assess the performance characteristics of genomic classification to systematic error from normal contamination, we collected 55 tumor samples and paired tumor-adjacent normal tissue.
These microenvironments provide a flexible and controlled system for systematic investigations into normal and pathologic morphogenic behaviours as well as synthetic environments for promoting tissue morphogenesis for regenerative medicine applications.
Towards this aim, we have now performed a systematic investigation under normal and stress conditions of classical nuclear import and key factors that are essential for nuclear trafficking.
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