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The tillage systems represented the main plots and three residue levels within each tillage treatment as subplots: no residue (0R), normal residue (1R) and twice-normal residue (2R).
A large fraction of human cancers harbour point mutations in the ras gene at codon 12, in which the normal residue is substituted by a Val, Asp or Cys residue.
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The normal (WT) R258 residue exists in a heterogeneous environment comprising polar Q262 and Q287 residues and non-polar L261 and F284 residues (shown in cyan).
The normal (WT) K185 residue (shown in orange) exists in a polar environment formed by N11, K209 (shown in cyan), and several water molecules (shown in blue).
The change would result in a STOP codon replacing the normal glutamine (Q) residue in the 13th exon.
This mutation was first reported in DCM patients and resulted in the substitution of a phenylalanine for the normal leucine at residue 84 in TnT.
Normal, quiescent keratocytes residue between collagen lamellae of the corneal stroma as a sparse population of flattened-cells [ 5], connecting to one other through a network of extensive processes [ 6].
A single-nucleotide variant consisting of a G>T transversion (TTG>TTT) at nucleotide 12026 (G12026T, c.252 G>T) in exon 9 was found in one DCM patient and would substitute a phenylalanine for the normal leucine at residue 84 (Leu84Phe).
By screening 4608 ENU-mutagenized F1 zebrafish (Mullins et al., 1994; Solnica-Krezel et al., 1994), we found one fish heterozygous for C to A transversion, predicted to change the normal tyrosine (Y) residue at amino acid 1031 to a premature stop codon (Fig. 1M).
The HD mutation comprises expanded versions of a polymorphic CAG repeat that elongate a variable polyglutamine segment in the huntingtin protein, from the normal range (8 37 residues) to 38 or more residues (1).
Abbreviations, mAb = monoclonal antibody; PrPc residues = normal cellular prion amino acid residues.
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