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As these experiments create non-physiological levels of miRNAs that may affect target mRNAs abnormally, accurate evaluation of the miRNA effects may require normal range of variations in miRNA expression under an endogenous condition.
There is a normal range of variations of size and shape in normal cells which it requires experience to recognize.
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"When we looked at this variability and compared it with modern humans, you can see this is a normal range of variation," Prof Lordkipanidze told BBC News.
A prime example from human evolution highlighting the difficulty of figuring out whether a new fossil falls within the normal range of variation of a known species is Homo floresiensis, a small hominin discovered in Indonesia (Brown et al. 2004).
As I see it, future research should focus on the independence of mania and hypomania from bipolar disorder, and the unsolved issue in adolescent psychiatry of whether hyperthymic behaviour in some adolescents remains within the normal range of variation of emotional development or emotional dysregulation (Päären et al. 2013).
In their view, traits associated with autism or other developmental disabilities are better regarded as differences within the normal range of variation as opposed to types of pathology.
This decision was later supported by further fieldwork that showed that the differences fell within the normal range of variation for the species.
Goldman synonymized the three as O. couesi mexicanus in 1918 and in 2009 Carleton and Arroyo-Cabrales concurred, arguing that the differences between rufus and mexicanus were age-related and within the normal range of variation of the animal.
The value of 30 nt for RS and RT was chosen empirically, observing the normal range of variation in the start and end positions of transcripts, and looking for a tradeoff between a more stringent definition of the isoform structures and the requirement to recognize similar isoforms.
For example, the normal range of variation in ventricular trabeculation is currently unknown.
However, the differences are probably not significant and are within the normal range of variation of an EMSA.
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