In conclusion, we have shown that Sp2 is required for normal progression of embryonic development, and that it is essential for survival of mouse embryos after E9.5.
This feedback inhibition renders the concentration of dNTPs at gastrulation robust, with respect to large variations in maternal supplies, and is essential for normal progression of embryogenesis.
For example, five testicular protein kinases,TSSK1, TSSK2, SSTK, CAMK4, and Haspin, are specifically expressed in haploid germ cells and two of these enzymes (CAMK4 and SSTK) are indispensable for normal progression of spermatogenesis and male fertility [13], [14], [15], [16].
TIMELESS is required for normal progression of S-phase and is involved in the circadian rhythm autoregulatory loop.
Taken together, these data suggest that Wnt/β-catenin signaling might be necessary for normal progression of the injury response during regeneration.
Certainly, the correct nutritional cues are necessary for normal progression of the oogenic cycle and so may also have an important role in maintaining developmental arrest.
We show that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme.
It was found that PXR-null mice showed impaired hepatocyte proliferation after partial hepatectomy suggesting that PXR is required for normal progression of liver regeneration by modulating hepatocyte proliferation (Dai et al, 2008).
In T-ALL, the prevailing model suggests that ectopically expressed SCL and LMO2 synergize to prevent the activity of E protein homodimers, essential for normal progression of T cell differentiation.
Since cytological and cytometric data [ 19, 29] indicate that apomictic plants in H. perforatum are characterized by a low occurrence of reduced embryo sacs, the decreased expression of critical genes for normal progression of meiosis supports the hypothesis that apospory in this species could be associated to a low rate of successful meiosis.
