It's not a progressive improvement over previous technologies; it breaks the normal paradigms of energy sources.
Pressing a button to wake it up or getting rattled by a buzzing notification breaks you out of the normal interaction paradigm that has been familiar to humans for a hundred years.
In the flowpath implementation of Java bytecodes the normal load execute store paradigm is represented as a single sequential operation and stack-manipulation operations become combinational thus executing faster.
They have transcended advertising: they are creating advertising so iconic, so nuanced, that it flips the normal advertising paradigm – content pushed relentlessly into our eyes and head, exposed to us against our will, like a flasher in a dreary park – entirely on its head.
In a normal metabolic paradigm, cellular energy demands are primarily met by oxygen-dependent mitochondrial metabolism of carbohydrates, fatty acids and amino acids in almost all cell types while oxygen-independent glycolysis accounts for only a fraction of cellular energy supply.
They did two things with Beck: they created the normal-cop-in-a-normal-city paradigm, the dour guy a little down on his luck; and they used a crime series explicitly as social critique.
In that form, in normal science, a paradigm is the conjunction of experiments, based on models, that can be copied or emulated.
The reason is that, as research continues filling gaps and further articulating the paradigm, normal science becomes more tightly integrated, logically and mathematically, as well as expanding into new levels of detail (new domains of research).
The lethality associated with UAS-endoAA66W was observed both in the absence of endogenous EndoA (in endoA nulls), and in the presence of EndoA in normal dosage (overexpression paradigm).
However, nothing like Kuhnian paradigms, normal science, and revolutions are to be found in Hull's book, and this was deliberate on his part.
Many scientists believe that thresholds exist and that normal risk assessment paradigms are appropriate for these substances, also in the light of very low exposure levels and the low intrinsic activity of most endocrine-active substances (Autrup et al. 2015; Borgert et al. 2013; Testai et al. 2013).
