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The ejection fraction also was unchanged, indicating normal myocardial function (Fig. 1E).
Both patient groups with normal myocardial function and with impaired myocardial function showed significant fluid responsiveness (that is, a decrease in PP variation after fluid loading) [ 1].
Our encouraging results that led to restoration of nearly normal myocardial function parameters have already prompted us to follow up on this path.
However, the overall similarity of cardiac defects between the whole-body and cardiomyocyte-specific KO mice strongly indicates a cell-autonomous role of NELF-B in supporting normal myocardial function.
For example, TETA treatment normalized myocardial copper content and could thus contribute to the maintenance or restoration of normal myocardial function in diabetes, by restoring myocellular copper transport and antioxidant defenses.
Group 4 (n = 30) were SSc controls who did not have evidence of cardiopulmonary complications, based on sPAPTTE < 30 mm Hg, normal myocardial function on TTE, DLCOcorr > 70% predicted, FEV1/FVC percentage predicted > 0.7, no ILD on HRCT (and in those without an HRCT, FVC ≥ 80% predicted), and WHO-FC I or II.
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An increased E/e′ might reflect impaired myocardial diastolic function but could also result from hypervolemia with normal myocardial diastolic function.
Pertinently, cardiac dysfunction reversibility in these pheochromocytoma-induced cardiomyopathies is well established; all six survivors were all weaned off ECMO within a week and recovered normal myocardial systolic function.
Integrin signaling is important in the maintenance of normal myocardial structure and function [ 24].
Quantitative functional parameters are generally used to classify a patient with a normal or abnormal myocardial function in the clinical setting.
In previous studies, PP variation derived by time-domain analysis was markedly decreased when compared to patients with normal or moderately impaired myocardial function [ 3, 14].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com