Blacker D, Lee H, Muzikansky A, Martin EC, Tanzi R, McArdle JJ, Moss M, Albert M. Neuropsychological measures in normal individuals that predict subsequent cognitive decline.
Some AD prevention trials are enrolling cognitively normal individuals that are genetically at high risk for developing AD who carry autosomal dominant FAD mutations (DIAN TU trial) or are homozygous for the apolipoprotein E ε4 allele (API trial).
This analysis clearly demonstrates the critical need for large arrays of good quality mtDNA sequences from normal individuals that encompass the full array of mtDNA lineages from around the world.
In RA, however, it has been reported that the number of CD4+CD25+ cells in peripheral blood is comparable to that in normal individuals, and that they accumulate in inflamed joints [ 47, 48], where they also suppress secretion of protective cytokines [ 48].
Indeed, this situation is interesting to study since it has been recently recognized in the literature the existence of different subtypes of obesity such as metabolically healthy but obese (elevated body fat but normal metabolic profiles) and metabolically obese, normal weight individuals that may be or not at increased cardiovascular risk.
One common assumption in regard to the motor behavior of handicapped people is that they are different from the so called normal individuals, difference that is invariably taken as synonymous of the handicap individual being slower, more variable, inaccurate, and inefficient than their normal counterpart.
Teixeira et al. [ 49] have suggested that SCH presents an intermediary lipid profile between that observed in normal individuals and that usually observed in OH.
Consistent with this idea are preliminary immunocytochemistry results on the testes of several normal older individuals that have been interpreted as possible spermatogonial microclones with altered signaling properties, but these clones have not been identified as carrying any mutation (46).
TRF length in fibroblasts from individuals in the early phase of WS has been shown to be comparable with that in cells from normal individuals, but that subsequently accelerated TRF shortening occurs [ 21].
Initiated by exposure to a defined stimulus that is usually tolerated by normal individuals and that causes broncho-constriction and airway infiltration of inflammatory cells in allergic individuals.
