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This case-control study identified women with pregnancies affected by fetal growth restriction and showed that their partners were more insulin resistant and more likely to smoke compared with fathers of normal grown offspring.
After multivariable analysis, men in the top quartile for insulin resistance who fathered a growth-restricted fetus had an OR 6.72 (95% CI 2.43 18.58; P < 0.0001) of having further risk factors for the insulin resistance syndrome and 3.36 (1.28–8.28; P < 0.013) of being a smoker compared with fathers of normal grown offspring.
Although our study provides objective evidence of subclinical insulin resistance at the time of fathering growth-restricted offspring, the Exeter Family Study of Childhood Health (EFSOCH), which studied almost 1,000 normal grown offspring and their fathers, did not find an association between offspring birth weight and paternal insulin resistance (10).
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